ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 194,706 Value ($000) $11,205 Avg Close — Range —
Q1 2015
Shares 34,491 Value ($000) $2,196 Avg Close — Range —
Q4 2014
Shares 16,673 Value ($000) $1,029 Avg Close — Range —
Q3 2014
Shares 7,426 Value ($000) $288 Avg Close — Range —
Q1 2014
Shares 14,726 Value ($000) $636 Avg Close — Range —