ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Connor, Clark & Lunn Investment Management Ltd.'s Holding History (CIK: 0001596800)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 5,900 Value ($000) $238 Avg Close — Range —
Q1 2014
Shares 8,935 Value ($000) $426 Avg Close — Range —