ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Point72 Asset Management, L.P.'s Holding History (CIK: 0001603466)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 71,500 Value ($000) $2,890 Avg Close — Range —
Q2 2015
Shares 140,100 Value ($000) $8,063 Avg Close — Range —