ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Compagnie Lombard Odier SCmA's Holding History (CIK: 0001615423)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 300 Value ($000) $17 Avg Close — Range —
Q1 2015
Shares 1,500 Value ($000) $96 Avg Close — Range —