ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Engineers Gate Manager LP's Holding History (CIK: 0001620220)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 9,801 Value ($000) $564 Avg Close — Range —
Q1 2015
Shares 5,933 Value ($000) $378 Avg Close — Range —