ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

C WorldWide Group Holding A/S's Holding History (CIK: 0001625244)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 91,060 Value ($000) $3,681 Avg Close — Range —
Q2 2015
Shares 90,700 Value ($000) $5,220 Avg Close — Range —
Q1 2015
Shares 98,100 Value ($000) $6,246 Avg Close — Range —
Q4 2014
Shares 126,180 Value ($000) $7,790 Avg Close — Range —
Q3 2014
Shares 187,500 Value ($000) $7,350 Avg Close — Range —