ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC's Holding History (CIK: 0001629649)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 14,090 Value ($000) $570 Avg Close — Range —
Q2 2015
Shares 14,090 Value ($000) $811 Avg Close — Range —