ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

EDMOND DE ROTHSCHILD HOLDING S.A.'s Holding History (CIK: 0001649647)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 238,405 Value ($000) $9,636 Avg Close — Range —
Q2 2015
Shares 201,105 Value ($000) $11,574 Avg Close — Range —