ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AG9 Class: NOTE 2.750%10/0

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 6,000,000 Value ($000) $14,963 Avg Close — Range —
Q4 2015
Shares 6,000,000 Value ($000) $22,421 Avg Close — Range —
Q3 2015
Shares 6,000,000 Value ($000) $14,685 Avg Close — Range —
Q2 2015
Shares 6,000,000 Value ($000) $20,839 Avg Close — Range —
Q1 2015
Shares 6,000,000 Value ($000) $23,048 Avg Close — Range —
Q4 2014
Shares 6,000,000 Value ($000) $22,294 Avg Close — Range —
Q3 2014
Shares 6,000,000 Value ($000) $14,505 Avg Close — Range —
Q2 2014
Shares 6,000,000 Value ($000) $13,208 Avg Close — Range —
Q1 2014
Shares 6,000,000 Value ($000) $16,099 Avg Close — Range —
Q4 2013
Shares 12,000,000 Value ($000) $29,835 Avg Close — Range —
Q3 2013
Shares 12,000,000 Value ($000) $28,058 Avg Close — Range —