ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AG9 Class: NOTE 2.750%10/0

ADVENT CAPITAL MANAGEMENT /DE/'s Holding History (CIK: 0001097278)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 4,857,000 Value ($000) $13,040 Avg Close — Range —
Q4 2013
Shares 11,834,000 Value ($000) $29,496 Avg Close — Range —
Q3 2013
Shares 12,209,000 Value ($000) $28,549 Avg Close — Range —
Q2 2013
Shares 11,425,000 Value ($000) $19,931 Avg Close — Range —