ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AG9 Class: NOTE 2.750%10/0

Nantahala Capital Management, LLC's Holding History (CIK: 0001472322)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 2,500,000 Value ($000) $9,372 Avg Close — Range —
Q3 2015
Shares 2,500,000 Value ($000) $6,166 Avg Close — Range —
Q2 2015
Shares 2,500,000 Value ($000) $8,713 Avg Close — Range —
Q1 2015
Shares 2,500,000 Value ($000) $9,650 Avg Close — Range —
Q4 2014
Shares 2,500,000 Value ($000) $9,319 Avg Close — Range —
Q3 2014
Shares 5,650,000 Value ($000) $13,765 Avg Close — Range —
Q2 2014
Shares 5,650,000 Value ($000) $12,504 Avg Close — Range —
Q1 2014
Shares 5,000,000 Value ($000) $13,509 Avg Close — Range —
Q4 2013
Shares 3,000,000 Value ($000) $7,479 Avg Close — Range —