ISIS PHARMACEUTICALS INC

CUSIP: 464337AH7 Class: CONV

ADVENT CAPITAL MANAGEMENT /DE/'s Holding History (CIK: 0001097278)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 51,024,000 Value ($000) $46,539 Avg Close — Range —
Q2 2015
Shares 35,875,000 Value ($000) $38,863 Avg Close — Range —
Q1 2015
Shares 24,937,000 Value ($000) $29,036 Avg Close — Range —
Q4 2014
Shares 40,505,000 Value ($000) $45,604 Avg Close — Range —