ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

LOOMIS SAYLES & CO L P's Holding History (CIK: 0000312348)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 656,832 Value ($000) $35,508 Avg Close — Range —
Q3 2018
Shares 656,983 Value ($000) $46,086 Avg Close — Range —
Q2 2018
Shares 572,994 Value ($000) $37,608 Avg Close — Range —
Q1 2018
Shares 239,496 Value ($000) $15,807 Avg Close — Range —
Q3 2017
Shares 178,649 Value ($000) $12,606 Avg Close — Range —
Q2 2017
Shares 710,705 Value ($000) $36,154 Avg Close — Range —
Q1 2017
Shares 699,403 Value ($000) $28,116 Avg Close — Range —
Q4 2016
Shares 758,154 Value ($000) $51,061 Avg Close — Range —