ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021
Shares 2,785,000 Value ($000) $2,822 Avg Close — Range —
Q4 2020
Shares 2,785,000 Value ($000) $3,009 Avg Close — Range —
Q3 2020
Shares 6,885,000 Value ($000) $7,115 Avg Close — Range —
Q2 2020
Shares 6,885,000 Value ($000) $7,590 Avg Close — Range —
Q1 2020
Shares 6,945,000 Value ($000) $7,029 Avg Close — Range —
Q4 2019
Shares 10,945,000 Value ($000) $12,522 Avg Close — Range —
Q3 2019
Shares 10,945,000 Value ($000) $12,482 Avg Close — Range —
Q2 2019
Shares 10,945,000 Value ($000) $12,943 Avg Close — Range —
Q1 2019
Shares 9,900,000 Value ($000) $13,383 Avg Close — Range —
Q4 2018
Shares 9,900,000 Value ($000) $10,594 Avg Close — Range —
Q3 2018
Shares 10,000,000 Value ($000) $10,500 Avg Close — Range —