ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

BLAIR WILLIAM & CO/IL's Holding History (CIK: 0000902367)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020
Shares 12,000 Value ($000) $13 Avg Close — Range —
Q3 2020
Shares 12,000 Value ($000) $12 Avg Close — Range —
Q2 2020
Shares 12,000 Value ($000) $13 Avg Close — Range —
Q1 2020
Shares 22,000 Value ($000) $22 Avg Close — Range —
Q4 2019
Shares 22,000 Value ($000) $25 Avg Close — Range —
Q3 2019
Shares 12,000 Value ($000) $14 Avg Close — Range —
Q2 2019
Shares 12,000 Value ($000) $14 Avg Close — Range —
Q1 2019
Shares 12,000 Value ($000) $16 Avg Close — Range —
Q4 2018
Shares 12,000,000 Value ($000) $13 Avg Close — Range —
Q2 2017
Shares 12,000 Value ($000) $13 Avg Close — Range —
Q1 2017
Shares 12,000 Value ($000) $13 Avg Close — Range —
Q4 2016
Shares 12,000 Value ($000) $12 Avg Close — Range —