ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

DEERFIELD MANAGEMENT COMPANY, L.P.'s Holding History (CIK: 0001009258)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 45,700,000 Value ($000) $45,283 Avg Close — Range —
Q4 2017
Shares 45,700,000 Value ($000) $48,392 Avg Close — Range —
Q3 2017
Shares 45,700,000 Value ($000) $48,504 Avg Close — Range —
Q2 2017
Shares 42,200,000 Value ($000) $44,891 Avg Close — Range —
Q1 2017
Shares 62,500,000 Value ($000) $60,243 Avg Close — Range —
Q4 2016
Shares 33,186,000 Value ($000) $33,802 Avg Close — Range —