ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

Clearbridge Investments, LLC's Holding History (CIK: 0001348883)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 2,936,000 Value ($000) $3,033 Avg Close — Range —
Q3 2016
Shares 4,936,000 Value ($000) $4,605 Avg Close — Range —
Q2 2016
Shares 4,936,000 Value ($000) $3,474 Avg Close — Range —
Q1 2016
Shares 4,936,000 Value ($000) $4,493 Avg Close — Range —
Q4 2015
Shares 4,500,000 Value ($000) $4,995 Avg Close — Range —