ISIS PHARMACEUTICALS INC DEL

CUSIP: 464337AJ3 Class: NOTE 1.000%11/1

CITADEL ADVISORS LLC's Holding History (CIK: 0001423053)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 24,000,000 Value ($000) $23,793 Avg Close — Range —
Q4 2017
Shares 26,000,000 Value ($000) $27,464 Avg Close — Range —
Q3 2017
Shares 30,500,000 Value ($000) $32,323 Avg Close — Range —
Q2 2017
Shares 21,500,000 Value ($000) $22,817 Avg Close — Range —
Q1 2017
Shares 9,957,000 Value ($000) $9,603 Avg Close — Range —
Q4 2016
Shares 35,457,000 Value ($000) $36,003 Avg Close — Range —
Q3 2016
Shares 14,000,000 Value ($000) $13,075 Avg Close — Range —
Q2 2016
Shares 51,500,000 Value ($000) $36,662 Avg Close — Range —
Q1 2016
Shares 57,500,000 Value ($000) $52,449 Avg Close — Range —
Q4 2015
Shares 44,500,000 Value ($000) $50,179 Avg Close — Range —