KALEIDO BIOSCIENCES INC

Ticker: KLDO CUSIP: 483347100 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 37,074 Value ($000) $300 Avg Close $10.89 Range $7.00 - $20.50

Q3 2020

Shares 13,000 Value ($000) $144 Avg Close $6.93 Range $5.04 - $11.89

Q2 2020

Shares 38,219 Value ($000) $284 Avg Close $6.70 Range $4.55 - $8.45

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	37,074	$300	$10.89	$7.00 - $20.50
Q3 2020	13,000	$144	$6.93	$5.04 - $11.89
Q2 2020	38,219	$284	$6.70	$4.55 - $8.45