KARYOPHARM THERAPEUTICS INC

CUSIP: 48576U106 Class: Common Stock

TOCQUEVILLE ASSET MANAGEMENT L.P.'s Holding History (CIK: 0000883961)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 30,000 Value ($000) $398 Avg Close — Range —
Q3 2015
Shares 30,000 Value ($000) $316 Avg Close — Range —
Q2 2015
Shares 29,750 Value ($000) $809 Avg Close — Range —
Q1 2015
Shares 14,300 Value ($000) $438 Avg Close — Range —