KARYOPHARM THERAPEUTICS INC

CUSIP: 48576U106 Class: Common Stock

EDMOND DE ROTHSCHILD HOLDING S.A.'s Holding History (CIK: 0001649647)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 15,000 Value ($000) $158 Avg Close — Range —
Q2 2015
Shares 50,000 Value ($000) $1,361 Avg Close — Range —