KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 3,794,236 Value ($000) $190,281 Avg Close — Range —
Q4 2014
Shares 3,398,491 Value ($000) $117,860 Avg Close — Range —
Q3 2014
Shares 3,398,491 Value ($000) $111,335 Avg Close — Range —
Q2 2014
Shares 3,398,491 Value ($000) $130,400 Avg Close — Range —
Q1 2014
Shares 3,279,635 Value ($000) $130,399 Avg Close — Range —
Q4 2013
Shares 2,251,998 Value ($000) $83,887 Avg Close — Range —
Q3 2013
Shares 2,419,470 Value ($000) $110,570 Avg Close — Range —
Q2 2013
Shares 2,163,235 Value ($000) $58,516 Avg Close — Range —