KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

MASSACHUSETTS FINANCIAL SERVICES CO /MA/'s Holding History (CIK: 0000912938)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 291,708 Value ($000) $14,629,156 Avg Close — Range —
Q4 2014
Shares 508,418 Value ($000) $17,631,936 Avg Close — Range —
Q3 2014
Shares 863,355 Value ($000) $28,284 Avg Close — Range —
Q2 2014
Shares 882,853 Value ($000) $33,875 Avg Close — Range —
Q1 2014
Shares 808,347 Value ($000) $32,139,876 Avg Close — Range —
Q4 2013
Shares 841,397 Value ($000) $31,426,178 Avg Close — Range —
Q3 2013
Shares 682,313 Value ($000) $31,105,967 Avg Close — Range —
Q2 2013
Shares 477,877 Value ($000) $12,926,573 Avg Close — Range —