KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 16,740 Value ($000) $1,255 Avg Close — Range —
Q2 2015
Shares 16,315 Value ($000) $1,228 Avg Close — Range —
Q1 2015
Shares 11,780 Value ($000) $591 Avg Close — Range —
Q4 2014
Shares 11,549 Value ($000) $400 Avg Close — Range —
Q3 2014
Shares 11,846 Value ($000) $388 Avg Close — Range —
Q2 2014
Shares 11,473 Value ($000) $440 Avg Close — Range —
Q1 2014
Shares 9,265 Value ($000) $368 Avg Close — Range —
Q4 2013
Shares 9,126 Value ($000) $340 Avg Close — Range —
Q3 2013
Shares 8,543 Value ($000) $391 Avg Close — Range —
Q2 2013
Shares 8,587 Value ($000) $232 Avg Close — Range —