KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 327,904 Value ($000) $24,586 Avg Close — Range —
Q2 2015
Shares 240,866 Value ($000) $18,140 Avg Close — Range —
Q1 2015
Shares 58,470 Value ($000) $2,933 Avg Close — Range —
Q4 2014
Shares 18,685 Value ($000) $648 Avg Close — Range —