KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 65,000 Value ($000) $4,874 Avg Close — Range —
Q4 2014
Shares 587,226 Value ($000) $20,365 Avg Close — Range —
Q3 2014
Shares 700,000 Value ($000) $22,932 Avg Close — Range —
Q2 2014
Shares 700,000 Value ($000) $26,859 Avg Close — Range —
Q1 2014
Shares 794,200 Value ($000) $31,577 Avg Close — Range —
Q4 2013
Shares 1,068,400 Value ($000) $39,905 Avg Close — Range —
Q3 2013
Shares 500,000 Value ($000) $22,795 Avg Close — Range —
Q2 2013
Shares 425,000 Value ($000) $11,496 Avg Close — Range —
Q1 2013
Shares 425,000 Value ($000) $10,353 Avg Close — Range —