KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 387,741 Value ($000) $29,201 Avg Close — Range —
Q1 2015
Shares 354,265 Value ($000) $17,766 Avg Close — Range —
Q4 2014
Shares 286,255 Value ($000) $9,927 Avg Close — Range —
Q3 2014
Shares 311,255 Value ($000) $10,197 Avg Close — Range —
Q2 2014
Shares 311,255 Value ($000) $11,943 Avg Close — Range —
Q1 2014
Shares 311,255 Value ($000) $12,375 Avg Close — Range —
Q4 2013
Shares 313,191 Value ($000) $11,698 Avg Close — Range —
Q3 2013
Shares 265,000 Value ($000) $12,081 Avg Close — Range —
Q2 2013
Shares 165,000 Value ($000) $4,463 Avg Close — Range —