KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,125,564 Value ($000) $84,395 Avg Close — Range —
Q2 2015
Shares 1,290,292 Value ($000) $97,172 Avg Close — Range —
Q1 2015
Shares 1,382,722 Value ($000) $69,344 Avg Close — Range —
Q4 2014
Shares 1,121,884 Value ($000) $38,907 Avg Close — Range —
Q3 2014
Shares 1,102,181 Value ($000) $36,107 Avg Close — Range —
Q2 2014
Shares 949,959 Value ($000) $36,450 Avg Close — Range —
Q1 2014
Shares 905,259 Value ($000) $35,993 Avg Close — Range —
Q4 2013
Shares 900,559 Value ($000) $33,636 Avg Close — Range —
Q3 2013
Shares 319,113 Value ($000) $14,548 Avg Close — Range —
Q2 2013
Shares 86,201 Value ($000) $2,332 Avg Close — Range —