KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 4,400 Value ($000) $331 Avg Close — Range —
Q1 2015
Shares 12,800 Value ($000) $642 Avg Close — Range —