LYRA THERAPEUTICS INC

CUSIP: 55234L105 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025
Shares 193,145 Value ($000) $24 Avg Close — Range —
Q4 2024
Shares 209,997 Value ($000) $43 Avg Close — Range —
Q3 2024
Shares 282,547 Value ($000) $73 Avg Close — Range —
Q2 2024
Shares 490,861 Value ($000) $136 Avg Close — Range —
Q1 2024
Shares 183,743 Value ($000) $1,143 Avg Close — Range —
Q4 2023
Shares 132,606 Value ($000) $695 Avg Close — Range —
Q3 2023
Shares 16,420 Value ($000) $64 Avg Close — Range —
Q2 2022
Shares 13,487 Value ($000) $76 Avg Close — Range —
Q4 2021
Shares 17,731 Value ($000) $77 Avg Close — Range —
Q3 2021
Shares 13,384 Value ($000) $122 Avg Close — Range —
Q2 2021
Shares 23,884 Value ($000) $192 Avg Close — Range —
Q1 2021
Shares 72,052 Value ($000) $835 Avg Close — Range —
Q4 2020
Shares 22,510 Value ($000) $257 Avg Close — Range —
Q2 2020
Shares 20,621 Value ($000) $234 Avg Close — Range —