LYRA THERAPEUTICS INC

CUSIP: 55234L105 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025
Shares 364,478 Value ($000) $46 Avg Close — Range —
Q4 2024
Shares 385,500 Value ($000) $80 Avg Close — Range —
Q3 2024
Shares 460,300 Value ($000) $118 Avg Close — Range —
Q2 2024
Shares 681,600 Value ($000) $189 Avg Close — Range —
Q1 2024
Shares 143,900 Value ($000) $895 Avg Close — Range —
Q4 2023
Shares 50,700 Value ($000) $266 Avg Close — Range —
Q1 2023
Shares 28,300 Value ($000) $57 Avg Close — Range —
Q4 2022
Shares 28,600 Value ($000) $90 Avg Close — Range —
Q3 2022
Shares 42,800 Value ($000) $214 Avg Close — Range —
Q2 2022
Shares 38,400 Value ($000) $217 Avg Close — Range —
Q1 2022
Shares 20,000 Value ($000) $80 Avg Close — Range —
Q4 2021
Shares 56,700 Value ($000) $247 Avg Close — Range —
Q3 2021
Shares 58,000 Value ($000) $529 Avg Close — Range —
Q2 2021
Shares 44,000 Value ($000) $353 Avg Close — Range —
Q1 2021
Shares 31,434 Value ($000) $364 Avg Close — Range —