MAST THERAPEUTICS INC

CUSIP: 576314108 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 13,044 Value ($000) $2 Avg Close — Range —
Q4 2016
Shares 297,739 Value ($000) $26 Avg Close — Range —
Q4 2015
Shares 23,411 Value ($000) $10 Avg Close — Range —
Q1 2015
Shares 23,697 Value ($000) $11 Avg Close — Range —