MEDICINES CO

CUSIP: 584688105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019
Shares 57,282 Value ($000) $4,866 Avg Close — Range —
Q2 2019
Shares 241,882 Value ($000) $8,821 Avg Close — Range —
Q1 2019
Shares 10,182 Value ($000) $285 Avg Close — Range —
Q2 2018
Shares 9,282 Value ($000) $341 Avg Close — Range —
Q4 2015
Shares 17,204 Value ($000) $642 Avg Close — Range —
Q1 2015
Shares 9,246 Value ($000) $259 Avg Close — Range —
Q4 2014
Shares 34,326 Value ($000) $950 Avg Close — Range —
Q2 2014
Shares 24,352 Value ($000) $708 Avg Close — Range —
Q1 2014
Shares 99,245 Value ($000) $2,821 Avg Close — Range —