MEDICINES CO

CUSIP: 584688105 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 25,542 Value ($000) $937 Avg Close — Range —
Q1 2018
Shares 10,782 Value ($000) $355 Avg Close — Range —