MEDICINES CO

CUSIP: 584688AC9 Class: 1.38% 06/01/17

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 4,225,000 Value ($000) $5,377 Avg Close — Range —
Q4 2015
Shares 8,225,000 Value ($000) $11,771 Avg Close — Range —
Q3 2015
Shares 8,225,000 Value ($000) $11,947 Avg Close — Range —
Q1 2015
Shares 3,000,000 Value ($000) $3,561 Avg Close — Range —