MELINTA THERAPEUTICS INC

CUSIP: 58549G100 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 315,905 Value ($000) $250 Avg Close — Range —
Q3 2018
Shares 59,399 Value ($000) $235 Avg Close — Range —
Q4 2017
Shares 14,851 Value ($000) $235 Avg Close — Range —