MILESTONE PHARMACEUTICALS IN

Ticker: MIST CUSIP: 59935V107 Class: COM

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 402,635 Value ($000) $813 Avg Close $2.15 Range $1.61 - $3.06

Q3 2025

Shares 401,559 Value ($000) $803 Avg Close $1.76 Range $1.36 - $2.56

Q1 2025

Shares 322,082 Value ($000) $258 Avg Close $1.99 Range $0.75 - $2.50

Q4 2024

Shares 2,703,259 Value ($000) $6,380 Avg Close $1.72 Range $1.40 - $2.75

Q3 2024

Shares 2,778,525 Value ($000) $4,223 Avg Close $1.45 Range $1.12 - $1.70

Q2 2024

Shares 2,749,930 Value ($000) $3,657 Avg Close $1.61 Range $1.22 - $1.87

Q1 2024

Shares 2,855,612 Value ($000) $5,112 Avg Close $1.62 Range $1.33 - $2.40

Q4 2023

Shares 1,494,489 Value ($000) $2,496 Avg Close $2.71 Range $1.62 - $3.52

Q3 2023

Shares 1,695,291 Value ($000) $5,255 Avg Close $3.11 Range $2.68 - $3.86

Q2 2023

Shares 1,751,168 Value ($000) $4,991 Avg Close $3.77 Range $2.73 - $4.49

Q1 2023

Shares 1,729,022 Value ($000) $7 Avg Close $3.66 Range $3.10 - $4.44

Q4 2022

Shares 1,995,029 Value ($000) $8 Avg Close $5.26 Range $3.39 - $9.72

Q3 2022

Shares 933,098 Value ($000) $8,575 Avg Close $7.58 Range $5.76 - $9.85

Q2 2022

Shares 1,358,362 Value ($000) $8,069 Avg Close $6.14 Range $5.06 - $7.68

Q1 2022

Shares 1,288,923 Value ($000) $8,275 Avg Close $6.25 Range $3.98 - $8.24

Q4 2021

Shares 985,867 Value ($000) $6,457 Avg Close $5.99 Range $5.21 - $7.38

Q3 2021

Shares 695,241 Value ($000) $3,970 Avg Close $5.64 Range $5.25 - $6.42

Q2 2021

Shares 718,630 Value ($000) $3,952 Avg Close $5.67 Range $5.09 - $6.22

Q1 2021

Shares 717,797 Value ($000) $4,156 Avg Close $7.32 Range $5.57 - $9.03

Q4 2020

Shares 715,786 Value ($000) $4,796 Avg Close $6.70 Range $5.32 - $7.97

Q3 2020

Shares 307,754 Value ($000) $2,253 Avg Close $7.17 Range $3.18 - $11.40

Q1 2020

Shares 191,858 Value ($000) $353 Avg Close $17.31 Range $1.69 - $23.25

Q4 2019

Shares 29,494 Value ($000) $472 Avg Close $17.77 Range $12.36 - $22.38

Q3 2019

Shares 23,704 Value ($000) $410 Avg Close $19.71 Range $15.10 - $27.73

Q2 2019

Shares 34,199 Value ($000) $929 Avg Close $20.62 Range $15.09 - $27.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	402,635	$813	$2.15	$1.61 - $3.06
Q3 2025	401,559	$803	$1.76	$1.36 - $2.56
Q1 2025	322,082	$258	$1.99	$0.75 - $2.50
Q4 2024	2,703,259	$6,380	$1.72	$1.40 - $2.75
Q3 2024	2,778,525	$4,223	$1.45	$1.12 - $1.70
Q2 2024	2,749,930	$3,657	$1.61	$1.22 - $1.87
Q1 2024	2,855,612	$5,112	$1.62	$1.33 - $2.40
Q4 2023	1,494,489	$2,496	$2.71	$1.62 - $3.52
Q3 2023	1,695,291	$5,255	$3.11	$2.68 - $3.86
Q2 2023	1,751,168	$4,991	$3.77	$2.73 - $4.49
Q1 2023	1,729,022	$7	$3.66	$3.10 - $4.44
Q4 2022	1,995,029	$8	$5.26	$3.39 - $9.72
Q3 2022	933,098	$8,575	$7.58	$5.76 - $9.85
Q2 2022	1,358,362	$8,069	$6.14	$5.06 - $7.68
Q1 2022	1,288,923	$8,275	$6.25	$3.98 - $8.24
Q4 2021	985,867	$6,457	$5.99	$5.21 - $7.38
Q3 2021	695,241	$3,970	$5.64	$5.25 - $6.42
Q2 2021	718,630	$3,952	$5.67	$5.09 - $6.22
Q1 2021	717,797	$4,156	$7.32	$5.57 - $9.03
Q4 2020	715,786	$4,796	$6.70	$5.32 - $7.97
Q3 2020	307,754	$2,253	$7.17	$3.18 - $11.40
Q1 2020	191,858	$353	$17.31	$1.69 - $23.25
Q4 2019	29,494	$472	$17.77	$12.36 - $22.38
Q3 2019	23,704	$410	$19.71	$15.10 - $27.73
Q2 2019	34,199	$929	$20.62	$15.09 - $27.95