NANOSPHERE INC

CUSIP: 63009F204 Class: Com

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 13,804 Value ($000) $23 Avg Close — Range —
Q1 2016
Shares 10,331 Value ($000) $8 Avg Close — Range —
Q4 2015
Shares 15,869 Value ($000) $10 Avg Close — Range —