NAVIDEA BIOPHARMACEUTICALS I

CUSIP: 63937X103 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 15,200 Value ($000) $14 Avg Close — Range —
Q4 2015
Shares 14,600 Value ($000) $19 Avg Close — Range —
Q3 2015
Shares 22,302 Value ($000) $51 Avg Close — Range —
Q2 2015
Shares 11,701 Value ($000) $19 Avg Close — Range —
Q1 2015
Shares 11,700 Value ($000) $19 Avg Close — Range —