NOVAN INC

CUSIP: 66988N205 Class: Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 65,831 Value ($000) $259 Avg Close — Range —
Q4 2021
Shares 185,952 Value ($000) $775 Avg Close — Range —