NOVELION THERAPEUTICS INC

CUSIP: 67001K202 Class: COM NEW

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2017
Shares 23,496 Value ($000) $73 Avg Close — Range —
Q1 2017
Shares 65,987 Value ($000) $709 Avg Close — Range —
Q4 2016
Shares 23,795 Value ($000) $200 Avg Close — Range —