NXSTAGE MEDICAL INC

CUSIP: 67072V103 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 11,796 Value ($000) $338 Avg Close — Range —
Q3 2018
Shares 16,015 Value ($000) $447 Avg Close — Range —
Q1 2018
Shares 44,529 Value ($000) $1,107 Avg Close — Range —
Q4 2017
Shares 93,552 Value ($000) $2,267 Avg Close — Range —
Q3 2017
Shares 149,865 Value ($000) $4,136 Avg Close — Range —
Q2 2017
Shares 92,261 Value ($000) $2,313 Avg Close — Range —
Q1 2017
Shares 282,669 Value ($000) $7,584 Avg Close — Range —
Q4 2016
Shares 320,232 Value ($000) $8,393 Avg Close — Range —
Q3 2016
Shares 365,381 Value ($000) $9,131 Avg Close — Range —
Q2 2016
Shares 367,069 Value ($000) $7,958 Avg Close — Range —
Q1 2016
Shares 454,356 Value ($000) $6,811 Avg Close — Range —
Q4 2015
Shares 451,945 Value ($000) $9,902 Avg Close — Range —
Q3 2015
Shares 212,373 Value ($000) $3,349 Avg Close — Range —
Q2 2015
Shares 420,605 Value ($000) $6,008 Avg Close — Range —
Q1 2015
Shares 152,888 Value ($000) $2,645 Avg Close — Range —
Q4 2014
Shares 29,259 Value ($000) $525 Avg Close — Range —
Q3 2013
Shares 51,340 Value ($000) $675 Avg Close — Range —
Q2 2013
Shares 122,248 Value ($000) $1,746 Avg Close — Range —