NXSTAGE MEDICAL INC

CUSIP: 67072V103 Class: COMMON STOCK

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2017
Shares 54,412 Value ($000) $1,318 Avg Close — Range —
Q3 2017
Shares 224,712 Value ($000) $6,202 Avg Close — Range —
Q2 2017
Shares 262,041 Value ($000) $6,569 Avg Close — Range —
Q1 2017
Shares 324,012 Value ($000) $8,693 Avg Close — Range —
Q4 2016
Shares 228,287 Value ($000) $5,983 Avg Close — Range —
Q3 2016
Shares 224,087 Value ($000) $5,600 Avg Close — Range —
Q2 2016
Shares 252,387 Value ($000) $5,472 Avg Close — Range —
Q1 2016
Shares 273,287 Value ($000) $4,097 Avg Close — Range —
Q4 2015
Shares 269,421 Value ($000) $5,903 Avg Close — Range —
Q3 2015
Shares 233,887 Value ($000) $3,724 Avg Close — Range —
Q2 2015
Shares 215,988 Value ($000) $3,085 Avg Close — Range —
Q1 2015
Shares 106,087 Value ($000) $1,835 Avg Close — Range —
Q4 2014
Shares 19,487 Value ($000) $349 Avg Close — Range —
Q2 2013
Shares 34,987 Value ($000) $499 Avg Close — Range —