OMEROS CORP

Ticker: OMER CUSIP: 682143102 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 524,757 Value ($000) $9,013 Avg Close $8.61 Range $4.06 - $17.65

Q3 2025

Shares 933,314 Value ($000) $3,827 Avg Close $3.97 Range $2.95 - $4.58

Q2 2025

Shares 670,219 Value ($000) $2,011 Avg Close $4.98 Range $2.97 - $9.16

Q1 2025

Shares 105,639 Value ($000) $868 Avg Close $8.83 Range $6.99 - $11.26

Q4 2024

Shares 162,991 Value ($000) $1,610 Avg Close $6.86 Range $3.75 - $13.60

Q3 2024

Shares 149,790 Value ($000) $595 Avg Close $4.27 Range $3.54 - $5.68

Q2 2024

Shares 159,446 Value ($000) $647 Avg Close $3.57 Range $2.61 - $4.41

Q1 2024

Shares 54,918 Value ($000) $189 Avg Close $3.80 Range $2.76 - $5.14

Q4 2023

Shares 47,600 Value ($000) $156 Avg Close $2.11 Range $0.92 - $3.81

Q3 2023

Shares 153,464 Value ($000) $448 Avg Close $4.01 Range $2.67 - $5.84

Q2 2023

Shares 59,800 Value ($000) $325 Avg Close $5.84 Range $4.35 - $7.80

Q1 2023

Shares 59,800 Value ($000) $278 Avg Close $3.61 Range $2.28 - $5.42

Q4 2022

Shares 199,237 Value ($000) $450 Avg Close $2.76 Range $1.74 - $4.00

Q3 2022

Shares 98,196 Value ($000) $309 Avg Close $4.64 Range $2.77 - $7.75

Q2 2022

Shares 687,904 Value ($000) $1,892 Avg Close $3.39 Range $1.86 - $6.41

Q1 2022

Shares 226,787 Value ($000) $1,363 Avg Close $6.24 Range $4.65 - $7.46

Q4 2021

Shares 548,318 Value ($000) $3,526 Avg Close $7.25 Range $5.45 - $9.78

Q3 2021

Shares 221,799 Value ($000) $3,059 Avg Close $14.97 Range $13.31 - $16.57

Q2 2021

Shares 395,319 Value ($000) $5,867 Avg Close $16.78 Range $13.86 - $19.39

Q1 2021

Shares 284,401 Value ($000) $5,062 Avg Close $19.45 Range $14.03 - $23.85

Q2 2020

Shares 87,852 Value ($000) $1,293 Avg Close $14.93 Range $11.84 - $17.21

Q1 2020

Shares 50,463 Value ($000) $675 Avg Close $13.30 Range $8.50 - $20.60

Q2 2017

Shares 87,319 Value ($000) $1,738 Avg Close $17.45 Range $13.56 - $27.09

Q1 2015

Shares 23,900 Value ($000) $527 Avg Close $22.83 Range $18.51 - $27.64

Q4 2014

Shares 81,889 Value ($000) $2,029 Avg Close $18.22 Range $11.18 - $25.10

Q2 2014

Shares 66,315 Value ($000) $1,154 Avg Close $12.61 Range $9.76 - $18.01

Q3 2013

Shares 12,600 Value ($000) $123 Avg Close $5.96 Range $4.75 - $10.70

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	524,757	$9,013	$8.61	$4.06 - $17.65
Q3 2025	933,314	$3,827	$3.97	$2.95 - $4.58
Q2 2025	670,219	$2,011	$4.98	$2.97 - $9.16
Q1 2025	105,639	$868	$8.83	$6.99 - $11.26
Q4 2024	162,991	$1,610	$6.86	$3.75 - $13.60
Q3 2024	149,790	$595	$4.27	$3.54 - $5.68
Q2 2024	159,446	$647	$3.57	$2.61 - $4.41
Q1 2024	54,918	$189	$3.80	$2.76 - $5.14
Q4 2023	47,600	$156	$2.11	$0.92 - $3.81
Q3 2023	153,464	$448	$4.01	$2.67 - $5.84
Q2 2023	59,800	$325	$5.84	$4.35 - $7.80
Q1 2023	59,800	$278	$3.61	$2.28 - $5.42
Q4 2022	199,237	$450	$2.76	$1.74 - $4.00
Q3 2022	98,196	$309	$4.64	$2.77 - $7.75
Q2 2022	687,904	$1,892	$3.39	$1.86 - $6.41
Q1 2022	226,787	$1,363	$6.24	$4.65 - $7.46
Q4 2021	548,318	$3,526	$7.25	$5.45 - $9.78
Q3 2021	221,799	$3,059	$14.97	$13.31 - $16.57
Q2 2021	395,319	$5,867	$16.78	$13.86 - $19.39
Q1 2021	284,401	$5,062	$19.45	$14.03 - $23.85
Q2 2020	87,852	$1,293	$14.93	$11.84 - $17.21
Q1 2020	50,463	$675	$13.30	$8.50 - $20.60
Q2 2017	87,319	$1,738	$17.45	$13.56 - $27.09
Q1 2015	23,900	$527	$22.83	$18.51 - $27.64
Q4 2014	81,889	$2,029	$18.22	$11.18 - $25.10
Q2 2014	66,315	$1,154	$12.61	$9.76 - $18.01
Q3 2013	12,600	$123	$5.96	$4.75 - $10.70