ONKURE THERAPEUTICS INC

Ticker: OKUR CUSIP: 68277Q105 Class: Com

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,320 Value ($000) $33 Avg Close $2.99 Range $2.53 - $3.63

Q3 2025

Shares 25,435 Value ($000) $70 Avg Close $2.48 Range $1.91 - $2.98

Q2 2025

Shares 25,862 Value ($000) $62 Avg Close $2.62 Range $1.70 - $4.32

Q1 2025

Shares 27,148 Value ($000) $117 Avg Close $5.62 Range $4.26 - $9.40

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,320	$33	$2.99	$2.53 - $3.63
Q3 2025	25,435	$70	$2.48	$1.91 - $2.98
Q2 2025	25,862	$62	$2.62	$1.70 - $4.32
Q1 2025	27,148	$117	$5.62	$4.26 - $9.40