OPHTHOTECH CORP

CUSIP: 683745103 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 232,825 Value ($000) $328 Avg Close — Range —
Q4 2018
Shares 173,134 Value ($000) $208 Avg Close — Range —
Q3 2018
Shares 82,738 Value ($000) $195 Avg Close — Range —
Q2 2018
Shares 151,135 Value ($000) $413 Avg Close — Range —
Q4 2017
Shares 117,527 Value ($000) $367 Avg Close — Range —
Q2 2017
Shares 23,570 Value ($000) $60 Avg Close — Range —
Q1 2017
Shares 329,797 Value ($000) $1,207 Avg Close — Range —
Q4 2016
Shares 107,830 Value ($000) $521 Avg Close — Range —
Q1 2015
Shares 93,907 Value ($000) $4,369 Avg Close — Range —
Q4 2014
Shares 11,474 Value ($000) $515 Avg Close — Range —
Q2 2014
Shares 7,714 Value ($000) $326 Avg Close — Range —
Q1 2014
Shares 10,400 Value ($000) $372 Avg Close — Range —