OPHTHOTECH CORP

CUSIP: 683745103 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 55,800 Value ($000) $79 Avg Close — Range —
Q4 2018
Shares 56,700 Value ($000) $68 Avg Close — Range —
Q3 2018
Shares 56,790 Value ($000) $134 Avg Close — Range —
Q2 2018
Shares 71,190 Value ($000) $194 Avg Close — Range —
Q1 2018
Shares 47,190 Value ($000) $129 Avg Close — Range —
Q4 2017
Shares 51,966 Value ($000) $162 Avg Close — Range —
Q3 2017
Shares 45,990 Value ($000) $130 Avg Close — Range —
Q2 2017
Shares 196,634 Value ($000) $503 Avg Close — Range —
Q1 2017
Shares 460,490 Value ($000) $1,685 Avg Close — Range —
Q4 2016
Shares 512,576 Value ($000) $2,476 Avg Close — Range —
Q1 2016
Shares 9,400 Value ($000) $397 Avg Close — Range —
Q1 2015
Shares 5,200 Value ($000) $242 Avg Close — Range —