OPTINOSE INC

CUSIP: 68404V100 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 38,300 Value ($000) $140 Avg Close — Range —
Q1 2020
Shares 20,532 Value ($000) $92 Avg Close — Range —
Q4 2019
Shares 30,151 Value ($000) $278 Avg Close — Range —
Q4 2018
Shares 104,184 Value ($000) $646 Avg Close — Range —