ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

Itau Unibanco Holding S.A.'s Holding History (CIK: 0001132597)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021
Shares 11,609 Value ($000) $27 Avg Close — Range —
Q2 2021
Shares 7,825 Value ($000) $34 Avg Close — Range —