ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020
Shares 2,000,000 Value ($000) $8,640 Avg Close — Range —
Q3 2020
Shares 2,000,000 Value ($000) $8,220 Avg Close — Range —
Q2 2020
Shares 3,000,000 Value ($000) $18,000 Avg Close — Range —
Q1 2020
Shares 3,052,000 Value ($000) $22,982 Avg Close — Range —
Q4 2019
Shares 3,739,084 Value ($000) $51,412 Avg Close — Range —
Q3 2019
Shares 3,358,084 Value ($000) $39,894 Avg Close — Range —
Q2 2019
Shares 1,730,800 Value ($000) $24,214 Avg Close — Range —
Q1 2019
Shares 1,074,800 Value ($000) $19,217 Avg Close — Range —
Q4 2018
Shares 1,074,800 Value ($000) $16,907 Avg Close — Range —